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Actor: Boman Irani, Aditi Bhatia, Aditi Rao Hydari.Language: Hindi. Status: Released. Director: Pankaj Kapur. Based on. Producer: Siddharth Roy Kapur. Cast: Boman Irani, Aditi Bhatia, Aditi Rao Hydari. Runtime: 1h 23mn. Genre: Comedy, Romance. DVDScr. Size: 476MB. Format: DVD. Region: All.The effects of alcohol on memory and the blood-brain barrier. Previous research has demonstrated a number of pharmacological effects of alcohol that might adversely influence memory. These include (a) memory deficits induced by the alcohol metabolites acetaldehyde and acetate; (b) disruption of the blood-brain barrier that occurs following ingestion of moderate amounts of alcohol and may lead to increased brain uptake of pharmacological agents; and (c) the specific effects of ethanol on brain neurotransmitter systems. The possible effects of alcohol on memory are discussed in the context of these known actions of the drug. In particular, the possibility of neurotoxic effects of ethanol (which includes the effects on the brain barrier) is considered in the context of studies of the effects of the drug on memory function.This program project addresses the question of how alcohol abuse and dependence develops. The program will use the powerful approaches of experimental genetics to address the nature of genetic contributions to alcohol and drug seeking behavior and the propensity for subsequent relapse. Four projects and two core units are proposed. In Project 1, Behavioral phenotyping of alcohol and drug response will be used to assess the behavioral consequences of genetic differences in the neuronal mechanisms of alcohol and drug responses. Using the selectively bred alcohol-preferring (P) and alcohol-nonpreferring (NP) rats as a model, alcohol reinforcement will be examined using a two-bottle choice procedure. A variety of measures of alcohol reinforcement will be assessed and comparisons will be made between the P and NP lines to determine if genetic differences in alcohol reinforcement exist. Project 2 proposes to determine if genetic differences in alcohol self-administration exist in the P and NP lines and to determine if such differences are accompanied by differences in alcohol reinforcement. In addition, the effects of targeted reductions in alcohol self-administration on alcohol reinforcement will be determined. Project 3 will use the 10 alcohol preferring (10P) and 10 alcohol non-preferring (10NP) lines of rats to determine if genetic differences in the functioning of central dopaminergic, glut
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